The adventures of three superheroes with the appearance of little girls, and their creator, an eminent scientist named Professor Utonium, who reside in Townsville, an imposing city with many skyscrapers. The girls are usually called by the mayor of the town to fight various monsters and antagonists. Each is identified by its own color: pink, blue and lime green. They have superpowers. In the meantime, they experience the daily life of any child their age, including sibling rivalry, loss of baby teeth, personal hygiene, schooling and other hobbies.